An Antiemetic has an effect on the body to prevent nausea, retching, and vomiting which are uncomfortable phenomena known as emesis. CBD may be useful for managing various types of nausea, including chemotherapy-induced nausea, motion sickness, and nausea associated with anxiety and stress.
The anti-nausea/anti-emetic effects of CBD may be mediated by indirect activation of somatodendritic 5-HT1A receptors in the dorsal raphe nucleus; activation of these autoreceptors reduces the release of 5-HT in terminal forebrain regions.